The Sour Wine

John 19:28-30 (ESV Strong's)

28 After this, Jesus, knowing that all was now finished, said (to fulfill the Scripture), “I thirst.” 29 A jar full of sour wine stood there, so they put a sponge full of the sour wine on a hyssop branch and held it to his mouth. 30 When Jesus had received the sour wine, he said, “It is finished,” and he bowed his head and gave up his spirit.

The sour wine is the tainted blood of our sin filling the cup of His sacrifice on our behalf. The blood of the sacrifice was usually sprinkled with hyssop. The word of God drank from the cup of God’s wrath for our sin. 

The Holy Spirit had already departed. Jesus the man was left to die on that cross alone.