Wisdom And Knowledge

Ecclesiastes 1:18 ESV
18 For in much wisdom is much vexation,
and he who increases knowledge increases sorrow.

Vexation includes includes the meanings of frustration, anger, and grief. Sorrow is the distress from loss or disappointment. These are the fruit of wisdom and knowledge apart from God. This is the fruit that became appealing by the deception of the serpent in the Garden.
Peace and joy are only found in the wisdom and knowledge of God.